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Superconducting-qubit readout via low-backaction electro-optic transduction

Nature - issue - St, 06/15/2022 - 00:00

Nature, Published online: 15 June 2022; doi:10.1038/s41586-022-04720-2

Readout of a superconducting qubit embedded in a circuit quantum electrodynamics architecture is demonstrated at optical frequencies through a low-noise electro-optomechanical transducer.

Androgen receptor blockade promotes response to BRAF/MEK-targeted therapy

Nature - issue - St, 06/15/2022 - 00:00

Nature, Published online: 15 June 2022; doi:10.1038/s41586-022-04833-8

Treatment with neoadjuvant BRAF/MEK-targeted therapy results in higher rates of major pathological response in female compared with male patients with melanoma, and pharmacological inhibition of androgen receptor signalling improved the responses of male and female mice to BRAF/MEK-targeted therapy.

Mechanism of replication origin melting nucleated by CMG helicase assembly

Nature - issue - St, 06/15/2022 - 00:00

Nature, Published online: 15 June 2022; doi:10.1038/s41586-022-04829-4

Cryo-electron microscopy structures of the sequential assembly of the CMG replicative helicase on a chromatinized origin of replication provide insights into the mechanism through which DNA melting is initiated by ATP binding.

A pan-cancer compendium of chromosomal instability

Nature - issue - St, 06/15/2022 - 00:00

Nature, Published online: 15 June 2022; doi:10.1038/s41586-022-04789-9

Copy number signatures characterize different types of chromosomal instability and predict drug response.

Deciphering the immunopeptidome in vivo reveals new tumour antigens

Nature - issue - St, 06/15/2022 - 00:00

Nature, Published online: 15 June 2022; doi:10.1038/s41586-022-04839-2

A newly developed genetically engineered mouse model enables the analysis of specific antigen presentation in vivo, providing insights into the tumour immunopeptidome and cancer progression.

Peptidoglycan maturation controls outer membrane protein assembly

Nature - issue - St, 06/15/2022 - 00:00

Nature, Published online: 15 June 2022; doi:10.1038/s41586-022-04834-7

Peptidoglycan stem peptides in the Gram-negative bacterial cell wall regulate the insertion of essential outer membrane proteins, thus representing a potential target for antibiotic design.

A population of ultraviolet-dim protoclusters detected in absorption

Nature - issue - St, 06/15/2022 - 00:00

Nature, Published online: 15 June 2022; doi:10.1038/s41586-022-04681-6

Lyman-α absorption observations from the Las Campanas Observatory are used to find a population of ultraviolet-dim protoclusters that contain few galaxies compared with their analogues in cosmological simulations.

Signatures of copy number alterations in human cancer

Nature - issue - St, 06/15/2022 - 00:00

Nature, Published online: 15 June 2022; doi:10.1038/s41586-022-04738-6

A new framework enables a pan-cancer reference set of copy number signatures derived from allele-specific profiles from different experimental assays.

Caspase-7 activates ASM to repair gasdermin and perforin pores

Nature - issue - St, 06/15/2022 - 00:00

Nature, Published online: 15 June 2022; doi:10.1038/s41586-022-04825-8

Caspase-7 cleaves and activates acid sphingomyelinase (ASM), which promotes the repair of gasdermin pores and thereby delays pore-driven lysis to allow other processes such as extrusion or apoptosis to occur before cell death.

Lifelong multilineage contribution by embryonic-born blood progenitors

Nature - issue - St, 06/15/2022 - 00:00

Nature, Published online: 15 June 2022; doi:10.1038/s41586-022-04804-z

In situ barcoding and fate mapping in mice reveals that an early wave of progenitor specification, driven by embryonic multipotent progenitor cells, gives rise to adult blood independently of haematopoietic stem cells.

Synthesis of a monolayer fullerene network

Nature - issue - St, 06/15/2022 - 00:00

Nature, Published online: 15 June 2022; doi:10.1038/s41586-022-04771-5

Using an interlayer bonding cleavage strategy, a two-dimensional monolayer fullerene network is prepared; its moderate bandgap makes it a potential candidate for use in two-dimensional electronic devices.

An exercise-inducible metabolite that suppresses feeding and obesity

Nature - issue - St, 06/15/2022 - 00:00

Nature, Published online: 15 June 2022; doi:10.1038/s41586-022-04828-5

A newly identified exercise-induced signalling metabolite—an amidated conjugate of lactate and phenylalanine—can reduce food intake and improve blood glucose homeostasis.

cGAS–STING drives the IL-6-dependent survival of chromosomally instable cancers

Nature - issue - St, 06/15/2022 - 00:00

Nature, Published online: 15 June 2022; doi:10.1038/s41586-022-04847-2

The survival of cells with chromosomal instability (CIN) depends on the cGAS–STING pathway, in which IL-6 and its receptor have a key role; this vulnerability can be exploited to treat tumours that display CIN.

Measurement of the bound-electron <i>g</i>-factor difference in coupled ions

Nature - issue - St, 06/15/2022 - 00:00

Nature, Published online: 15 June 2022; doi:10.1038/s41586-022-04807-w

By trapping and crystallizing two highly charged ions of different neon isotopes in the same potential, a high-precision measurement of the bound-electron g-factor difference is obtained.

Molecular soccer balls connected to make a 2D material

Nature - issue - St, 06/15/2022 - 00:00

Nature, Published online: 15 June 2022; doi:10.1038/d41586-022-01568-4

Two-dimensional materials made of carbon have been limited to monolayers of atoms, such as graphene. Sheets composed of connected buckyballs — spherical clusters of atoms — have now been made by peeling layers from a crystal.

Tiny isotopic difference tests standard model of particle physics

Nature - issue - St, 06/15/2022 - 00:00

Nature, Published online: 15 June 2022; doi:10.1038/d41586-022-01569-3

A high-precision comparison of the magnetic moments of two isotopically different neon ions opens a path to the search for elusive particles that could explain the unexpectedly low observed mass of the Higgs boson.

Exercise molecule burns away hunger

Nature - issue - St, 06/15/2022 - 00:00

Nature, Published online: 15 June 2022; doi:10.1038/d41586-022-01321-x

A metabolite called Lac-Phe is associated with exercise-induced ‘muscle burn’. This molecule has now been shown to reduce food intake after exercise in mice, racehorses and humans, and to trigger weight loss in obese mice.

Ancient DNA traces origin of Black Death

Nature - issue - St, 06/15/2022 - 00:00

Nature, Published online: 15 June 2022; doi:10.1038/d41586-022-01673-4

Genomes show that plague-causing bacteria found in Kyrgyzstan graves are direct ancestors of those that triggered the medieval pandemic.

We regret to inform you that your choice of Deathday is no longer available

Nature - issue - St, 06/15/2022 - 00:00

Nature, Published online: 15 June 2022; doi:10.1038/d41586-022-01437-0

A change of pace.

Diversity in science prizes: why is progress so slow?

Nature - issue - St, 06/15/2022 - 00:00

Nature, Published online: 15 June 2022; doi:10.1038/d41586-022-01608-z

Many prize-givers still don’t publish details of nominations — a key step towards ensuring that awards are fair and unbiased.

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