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Menacing ‘famine weed’ grows more toxic as carbon levels soar

Nature - issue - St, 06/09/2021 - 00:00

Nature, Published online: 09 June 2021; doi:10.1038/d41586-021-01539-1

A highly invasive weed might owe some of its success to easier access to carbon, a key component of the weed’s toxin.

Perovskite decomposition and missing crystal planes in HRTEM

Nature - issue - St, 06/09/2021 - 00:00

Nature, Published online: 09 June 2021; doi:10.1038/s41586-021-03423-4

Perovskite decomposition and missing crystal planes in HRTEM

Reply to: Perovskite decomposition and missing crystal planes in HRTEM

Nature - issue - St, 06/09/2021 - 00:00

Nature, Published online: 09 June 2021; doi:10.1038/s41586-021-03424-3

Reply to: Perovskite decomposition and missing crystal planes in HRTEM

Google AI beats humans at designing computer chips

Nature - issue - St, 06/09/2021 - 00:00

Nature, Published online: 09 June 2021; doi:10.1038/d41586-021-01558-y

An AI that designs computer chips in hours, and zooming in on DNA’s complex 3D structures.

A graphical guide to ischaemic heart disease

Nature - issue - St, 06/09/2021 - 00:00

Nature, Published online: 09 June 2021; doi:10.1038/d41586-021-01450-9

Globally, 9 million people die each year from ischaemic heart disease. Despite falling rates of heart disease, tackling it is still a stubborn challenge.

Heart health

Nature - issue - St, 06/09/2021 - 00:00

Nature, Published online: 09 June 2021; doi:10.1038/d41586-021-01449-2

Research is revealing the causes of heart disease and what can be done to tackle the world’s biggest killer.

Observation of first and second sound in a BKT superfluid

Nature - issue - St, 06/09/2021 - 00:00

Nature, Published online: 09 June 2021; doi:10.1038/s41586-021-03537-9

First and second sound are experimentally observed in a two-dimensional superfluid, and the temperature-dependent sound speeds reveal the predicted jump in the superfluid density at the infinite-order Berezinskii–Kosterlitz–Thouless transition.

Quantum-enhanced nonlinear microscopy

Nature - issue - St, 06/09/2021 - 00:00

Nature, Published online: 09 June 2021; doi:10.1038/s41586-021-03528-w

A quantum microscope obtains signal-to-noise beyond the photodamage limits of conventional microscopy, revealing biological structures within cells that would not otherwise be resolved.

Experimental observation of non-Abelian topological charges and edge states

Nature - issue - St, 06/09/2021 - 00:00

Nature, Published online: 09 June 2021; doi:10.1038/s41586-021-03521-3

Non-Abelian topological charges and edge states in a PT-symmetric transmission line network are experimentally observed, and a non-Abelian quotient relation for the bulk–edge correspondence is found.

Anisotropic satellite galaxy quenching modulated by black hole activity

Nature - issue - St, 06/09/2021 - 00:00

Nature, Published online: 09 June 2021; doi:10.1038/s41586-021-03545-9

An analysis of archival data from the Sloan Digital Sky Survey finds that star-forming satellite galaxies are relatively more common along the minor axis of central galaxies owing to the effect of black hole feedback.

Representational drift in primary olfactory cortex

Nature - issue - St, 06/09/2021 - 00:00

Nature, Published online: 09 June 2021; doi:10.1038/s41586-021-03628-7

All odours elicit a unique pattern of neuronal activity in primary olfactory cortex but these patterns drift over time, posing a problem for the perceptual constancy of odours.

<i>NORAD</i>-induced Pumilio phase separation is required for genome stability

Nature - issue - St, 06/09/2021 - 00:00

Nature, Published online: 09 June 2021; doi:10.1038/s41586-021-03633-w

The noncoding RNA NORAD maintains genome stability in mammalian cells by sequestering Pumilio proteins in phase-separated compartments.

Tracing the origin of hair follicle stem cells

Nature - issue - St, 06/09/2021 - 00:00

Nature, Published online: 09 June 2021; doi:10.1038/s41586-021-03638-5

Live imaging and single-cell transcriptomics of mouse hair follicles reveal their development from 2D concentric zones in the placode to 3D longitudinal compartments, one of which is a stem cell compartment.

TIM-3 restrains anti-tumour immunity by regulating inflammasome activation

Nature - issue - St, 06/09/2021 - 00:00

Nature, Published online: 09 June 2021; doi:10.1038/s41586-021-03626-9

Mouse genetic studies and single-cell transcriptome analysis demonstrate that TIM-3 on dendritic cells has a key role in regulating antitumour immunity via inflammasome activation and is a potential target for anticancer therapy.

A graph placement methodology for fast chip design

Nature - issue - St, 06/09/2021 - 00:00

Nature, Published online: 09 June 2021; doi:10.1038/s41586-021-03544-w

Machine learning tools are used to greatly accelerate chip layout design, by posing chip floorplanning as a reinforcement learning problem and using neural networks to generate high-performance chip layouts.

Concerted cutting by Spo11 illuminates meiotic DNA break mechanics

Nature - issue - St, 06/09/2021 - 00:00

Nature, Published online: 09 June 2021; doi:10.1038/s41586-021-03389-3

A small proportion of Spo11-dependent DNA double-strand breaks are ‘double cuts’—adjacent breaks that occur in concert—revealing that gap repair during meiosis includes that of DNA gaps generated by Spo11 itself.

Tomographic reconstruction of oxygen orbitals in lithium-rich battery materials

Nature - issue - St, 06/09/2021 - 00:00

Nature, Published online: 09 June 2021; doi:10.1038/s41586-021-03509-z

High-energy X-ray Compton measurements and first-principles modelling reveal how the electronic orbital responsible for the reversible anionic redox activity can be imaged and visualized, and its character and symmetry determined.

Defining genome architecture at base-pair resolution

Nature - issue - St, 06/09/2021 - 00:00

Nature, Published online: 09 June 2021; doi:10.1038/s41586-021-03639-4

Micro Capture-C allows physical contacts to be determined at base-pair resolution, revealing that transcription factors have an important role in the maintenance of the contacts between enhancers and promoters.

Spo11 generates gaps through concerted cuts at sites of topological stress

Nature - issue - St, 06/09/2021 - 00:00

Nature, Published online: 09 June 2021; doi:10.1038/s41586-021-03632-x

Meiotic recombination in yeast is not only initiated by single break sites, but also caused by closely spaced Spo11-dependent double-stranded DNA breaks that create chromosomal gaps.

A 4D road map for the formation of hair follicles

Nature - issue - St, 06/09/2021 - 00:00

Nature, Published online: 09 June 2021; doi:10.1038/d41586-021-01482-1

Combined imaging and gene-expression analyses reveal that the arrangement of cells in concentric rings in the disc-like structures that give rise to hair follicles predetermines their eventual fate and location in mature follicles.

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